Utility of unfractionated sodium heparin in the prevention of disseminated intravascular coagulation
DOI:
https://doi.org/10.62486/agsalud2025107Keywords:
Unfractionated heparin, Disseminated intravascular coagulation, Prevention, AnticoagulantAbstract
Introduction: disseminated intravascular coagulation (DIC) is a serious disease characterized by a generalized activation of blood coagulation, with sequelae ranging from thrombus formation to severe bleeding.
Objective: to analyze the fundamental alternatives for the management of DIC prevention related to the use of unfractionated heparin.
Method: data collection was carried out through a search in the digital databases PUBMED, SCIELO (Scientific Electronic Library Online) and GOOGLE ACADEMIC. The articles were downloaded from the aforementioned platforms, and the Zotero system was used to make the corresponding citations and pertinent references.
Results: according to the results achieved, the systematic review allowed to obtain a more detailed view of the studies arising from the data search, related to DIC and the use of unfractionated heparin in its prevention. The importance of research related to this drug was highlighted to improve the understanding and treatment of DIC with the aim of reducing its morbidity and mortality.
Conclusions: despite unfractionated heparin presenting significant anticoagulant effects in its clinical utility, mainly in emergency situations due to its rapid action, there are few studies available for a better understanding of the management and functionality of UFH against DIC
References
1. Mogollón Gallo JD, Merchán Figueroa MK, Gualdrón Frías CA, Parra Pinzón PA, Niño Rodríguez DP, Obando Busto VJ. Coagulación intravascular diseminada. Dialnet [Internet]. 2020 [citado 2024 Sep 07]. 33(2):75–84. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=8154387
2. Hernández-Martínez A, Martínez- Sanchez LM. Coagulación intravascular diseminada: Una revisión de tema. [Internet]. 2018 [citado 2024 Sep 07]. 20(3):283. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0124-71072018000300283
3. Zamora Tapia ID, Poveda Paredes FX. Importance of sepsis diagnosis in the clinical laboratory. Salud, Ciencia y Tecnología [Internet]. 2024; 4:704. Available from: https://doi.org/10.56294/saludcyt2024704
4. Levi M, Scully M. How I treat disseminated intravascular coagulation. [Internet]. 2018 [citado 2024 Sep 07]. 131(8):845–54. Disponible en: https://ashpublications.org/blood/article/131/8/845/104418/How-I-treat-disseminated-intravascular-coagulation
5. Wada H, Matsumoto T, Yamashita Y. Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines. [Internet]. 2014 [citado 2024 Sep 07]. 2(1):15. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25520831/
6. Hirsh J, Anand SS, Halperin JL, Fuster V. Mechanism of Action and Pharmacology of Unfractionated Heparin. [Internet]. 2001 [citado 2024 Sep 07]. 21(7). Disponible en: https://pubmed.ncbi.nlm.nih.gov/11451734/
7. Beurskens DMH, Huckriede JP, Schrijver R, Hemker HC, Reutelingsperger CP, Nicolaes GAF. The Anticoagulant and Nonanticoagulant Properties of Heparin. [Internet]. 2020 [citado 2024 Sep 07]. 120(10). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32820487/
8. Aoki N, Matsuda T, Saito H, Takatsuki K, Okajima K, Takahashi H, et al. A Comparative Double- Blind Randomized Trial of Activated Protein C and Unfractionated Heparin in the Treatment of Disseminated Intravascular Coagulation. [Internet]. 2002 [citado 2024 Sep 07]. 75(5). Disponible en: https://pubmed.ncbi.nlm.nih.gov/12095157/
9. Omidkhoda N, Abedi F, Ghavami V, Rahimi H, Samadi S, Arasteh O, et al. The Effect of Heparin and Its Preparations on Disseminated Intravascular Coagulation Mortality and Hospitalization: A Systematic Review. Mansour A, organizador. [Internet]. 2022 [citado 2024 Sep 07]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35855054/
10. Hirsh J, Raschke R. Heparin and Low-Molecular-Weight Heparin. [Internet]. 2004 [citado 2024 Sep 07]. 126(3). Disponible en: https://pubmed.ncbi.nlm.nih.gov/11157643/
11. Michael B. Coagulación intravascular diseminada. [Internet]. 2018 [citado 2024 Sep 07]. Disponible en: https://www.msdmanuals.com/es/professional/hematolog%C3%ADa-y-oncolog%C3%ADa/trastornos-de-coagulaci%C3%B3n/coagulaci%C3%B3n-intravascular-diseminada-cid
12. Di Nisio M, Baudo F, Cosmi B, D’Angelo A, De Gasperi A, Malato A, et al. Diagnosis and treatment of disseminated intravascular coagulation: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). [Internet]. 2012 [citado 2024 Sep 07]. 129(5). Disponible en: https://pubmed.ncbi.nlm.nih.gov/21930293/
13. Iba T, Helms J, Connors JM, Levy JH. The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation. [Internet]. 2023 [citado 2024 Sep 07]. 11(1). Disponible en: https://pubmed.ncbi.nlm.nih.gov/37221630/
14. Vasconcelos Alves Melo M, Estrin MA. Pharmacological and Non-pharmacological interventions for the prevention of Pre-eclampsia: a Systematic Review. SCT Proceedings in Interdisciplinary Insights and Innovations [Internet]. 2023 Nov. 18;1:164. https://doi.org/10.56294/piii2023164
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Klender Siqueira de Negreiros , Anibal Danilo Farias (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
