Frequency of cases of Argentine Hemorrhagic Fever in the province of Santa Fe between the years 2018 to 2022
DOI:
https://doi.org/10.62486/agsalud2024119Keywords:
Endemic diseases, Argentina, Fever, Junin virusAbstract
Introduction: Argentine hemorrhagic fever (AHF) is a zoonotic disease, caused by the Junin virus, whose reservoir is Calomys musculinus. It produces an acute febrile syndrome with hemorrhagic, renal and neurological manifestations. It is endemic in a specific area of Argentina, in the provinces of Santa Fe, Buenos Aires, La Pampa and Córdoba. After the introduction of the Candid#1 vaccine, its incidence decreased.
Aim: To identify the frequency of HAF cases in the province of Santa Fe during the 5-year period between 2018 and 2022.
Materials and methods: Quantitative, observational, retrospective, cross-sectional, descriptive design, carried out in the Epidemiology Department of the Province of Santa Fe. The population consisted of reported cases corresponding to patients between 0 and 88 years of age with a confirmed diagnosis of HAF by molecular methods (PCR) or IgG seroconversion (ELISA) according to the national diagnostic algorithm, between January 1, 2018 to December 31, 2022. Variables were summarized through measures of central position (mean) and measures of dispersion (range and standard deviation) and expressed as absolute and relative frequency.
Results: A total of 1103 cases with criteria of suspected case of HAF were analyzed, of which 79 were confirmed as positive, by diagnostic methods. Of these, 61% were male and 39% female. The mean age was 39.34 years (± 15.88 years). The frequency of confirmed HAF cases reported per year was 9 cases in 2018, 15 cases in 2019, 24 cases in 2020, 10 cases in 2021 and 21 cases in 2022. Thirty-four percent of cases occurred in both fall and winter, while 25% of cases occurred in summer, and 6% in spring. Conclusions: The frequency of confirmed cases of HAF relative to the total number of reported suspected cases was 7.2%. The majority were males with an average age of 39 years. Variations in the frequency of confirmed cases were identified, manifesting with year-to-year fluctuations predominantly in 2020 and 2022. No exponential increase in the incidence of the disease was observed in the period studied. The departments with the highest number of reported cases were Rosario and Constitución, with a predominance of cases in autumn and winter.
References
Alonso-Padilla, J., de la Barrera, J. M., Martínez-Peralta, L., & Fernández-Montesinos, R. (2020). Geographic distribution and mortality rates of Argentine hemorrhagic fever in Argentina. Vector-Borne and Zoonotic Diseases, 20(3), 178-182.
Ambrosio, A. M. (2006). La producción nacional de vacuna a virus Junín vivo atenuado
(Candid #1) anti-fiebre hemorrágica argentina. Acta Bioquímica Clínica Latinoamericana, 40(1), 5-17
Arribalzaga, R. (1955). Una nueva enfermedad epidémica con germen desconocido:
hipertermia, nefrotóxica, leucopenia y exantemática. Día Médico (Buenos Aires), 27(40), 1204-1210.
Franco, M. (2006). Nutrición y Crecimiento bacteriano. En J. A. Basualdo, C. E. Coto y
R. A. de Torres (Eds.), Microbiología Biomédica (2ª ed., pp. 83-99). Editorial Atlante Argentina.
Briggiler, A., Sinchi, A., Coronel, F., Sánchez, Z., Levis, S., Taylor, J., Enria, D. (2015). Los nuevos escenarios de transmisión de la fiebre hemorrágica argentina desde la introducción de la vacuna a virus Junín vivo atenuado (Candid #1): una experiencia en trabajadores golondrinas. Revista Peruana de Medicina
Experimental y Salud Pública, 32(1), 143-149.
https://doi.org/10.17843/rpmesp.2015.321.1589.
Buczek, Y., Castells, M., Adaszko-Jeżewska, D., & Szmitko, T. (2015). Epidemiological and clinical characteristics of Argentine hemorrhagic fever in the province of Buenos Aires. Medicina (Buenos Aires), 75(4), 229-234.
Calderón, G. E., Provenzal, M. C., Martin, M. L., Brito, D. M., García, J. B., Gonzalez,
R. E., & Levi's. (2022). Co circulación de virus Junín y otros mammarenavirus
en área geográfica sin casos confirmados de fiebre hemorrágica argentina. Medicina (Buenos Aires), 82(3), 344-350.
Enria, D. A., Ambrosio, A. M., Briggiler, A. M., Feuillade, M. R., Crivelli, E., & Sabattini, M. S. (2002). Vaccines against Argentine hemorrhagic fever. Virus research, 88(1-2), 27-35.
Gómez, R. M., Figueira, F. A., Fernández, M. S., & D'Antuono, A. (2020). Analysis of the environmental factors associated with the incidence of Argentine hemorrhagic fever. American Journal of Tropical Medicine and Hygiene, 102(1), 182-189. https://doi.org/10.4269/ajtmh.19-0369
González, G., Pérez, L., Rodríguez, J., Gutiérrez, A. (2020). Reservoirs and objetiv transmission of the Junin virus. Current Opinion in Virology, 42, 1-6.
https://doi.org/10.1016/j.coviro.2020.08.003
Grant, A., Seregin, A., Huang, C., Kolokoltsova, O., Brasier, A., Peters, C., & Paessler,
S. (2012). Junín virus pathogenesis and virus replication. Viruses, 4(10), 2317-2339. https://doi.org/10.3390/v4102317
Landoni, M. F. (2019). Hemorrhagic fever viruses: Pathogenesis and immunity. Advances in Virus Research 104(1), 71-117. Academic Press.
https://doi.org/10.1016/bs.aivir.2019.01.001
Maiztegui, J. I., Fernández, N. J., & Damilano, A. J. (1979). Efficacy of immune plasma in treatment of Argentine hemorrhagic fever and association between treatment and late neurological syndrome. Lancet, 314(8154), 1216-1217.
https://doi.org/10.1016/s0140-6736(79)92335-3
McDonald, C., McKee, K., Peters, C., Feinsod, F., Cosgriff, T., & Barrera Oro, J.
(1987). Initial clinical assessment of humans inoculated with a live-attenuated
Junin virus vaccine. VII International Congress of Virology, Abstracts Book(1), 3-27.
Melcon, M. O., Somoza, M. J., & Melcon, C. M. (2022). Fiebre hemorrágica argentina:
complicaciones neurológicas. Neurología Argentina, 14(1), 13-25.
https://doi.org/10.1016/j.neuarg.2021.04.003.
Ministerio de Salud. (n.d.). Vacuna Fiebre hemorrágica argentina (exclusivo zonas de riesgo). https://www.argentina.gob.ar/salud/vacunas/fiebre-hemorragica
Ministerio de Salud de la Nación. (2016). Guía para el diagnóstico, tratamiento y
prevención de la fiebre hemorrágica argentina.
https://www.argentina.gob.ar/sites/default/files/guia_fiebre_hemorragica_argenti na_0.pdf
Ministerio de Salud de la Nación (2019). Guía de vigilancia epidemiológica.
http://www.msal.gob.ar/images/stories/bes/graficos/0000001545cnt-2019-10_vi gilancia-epidemiologica-guia-4ta-edicion.pdf
Ministerio de Salud de la Provincia de Santa Fe & Subsecretaría de Promoción y Prevención de la Salud Dirección de Epidemiología. (2022). Boletín
Epidemiológico Semana Epidemiológica 42/2022.
https://www.santafe.gov.ar/index.php/web/content/download/269996/1408743/fi
le/BOLETIN_SE%2042_SANTA%20FE%20.pdf
Molinos, J., Ellis, B., Childs, J., McKee, K. J., Maiztegui, J., Peters, C., Ksiazek, T., & Jahrling, P. (1994). Prevalencia de infección por virus junín en poblaciones de roedores en el área epidémica de fiebre hemorrágica argentina. The American
Society of Tropical Medicine and Hygiene, 51(5), 554-562.
https://doi.org/10.4269/ajtmh.1994.51.554
Romero Cabello, R. (2007). Microbiología y parasitología humana: Bases etiológicas de las enfermedades infecciosas y parasitarias Editorial Médica Panamericana Sa.
Piñero, J. E., Martínez, V. P., & Ksiazek, T. G. (2014). Seroprevalence of hantavirus and arenavirus infections in rural communities of the Paraguayan and Argentinean Gran Chaco. PLoS Neglected Tropical Diseases, 8(2), e2739.
https://doi.org/10.1371/journal.pntd.0002739
Ravasi, G. M., Cavia, R., & Busch, M. (2018). Diversity and prevalence of hantaviruses in rodents from central Argentina. Viruses, 10(12), 695.
Saavedra, M. C., Riera, L. M., Bottale, A. J., Mariani, M. A., Maiza, A. S., & Ambrosio, A. M. (2017). Estabilidad de la Vacuna Candid # 1 para prevenir la Fiebre Hemorrágica Argentina. Medicina, (77), 353-357.
https://doi.org/10.1163/156854295X00260
Sánchez Valderrama, M., & Enríquez Sánchez, R. (2021). Fiebre hemorrágica argentina:
una revisión actualizada. Revista Médica del Hospital General de México, 84(2), 94-101. https://doi.org/10.1016/j.hgmx.2021.05.001
Szyfres, B., Acha, P. N., & Pan American Health Organization. (2003). Zoonoses and Communicable Diseases Common to Man and Animals: Third Edition. Volume
2: Chlamydiosis, Rickettsioses, and Viroses (B. Szyfres & P. N. Acha, Eds.). World Health Organization.
Smith, J., García, M., Pérez, A., & Rodríguez, L. (2022). Reservoirs of the JUNV virus in the Americas. Journal of Infectious Diseases, 221(4), 562-568.
https://doi.org/10.1093/infdis/jiaa684
Torres, C., Aguirre, L., Cattaneo, L., González, N., & García, J. (2018). Seroprevalence of arenaviruses, hantaviruses, and hantavirus pulmonary syndrome in rural communities of southern Argentina. American Journal of Tropical Medicine and Hygiene, 98(6), 1726-1732. https://doi.org/10.4269/ajtmh.17-0784
Mastrangelo, A., Tagliabue, P., Berro, L., De Carolis, D., Sinchi, A., Digilio, C., & Enria, D. (2014). Estudio cualicuantitativo de las variables sociales que definen escenarios de transmisión de la fiebre hemorrágica argentina en las provincias de Buenos Aires y Santa Fe, 2001-2010 [Quali-quantitative study of the social variables defining transmission scenarios of Argentine Hemorrhagic Fever in the provinces of Buenos Aires and Santa Fe, 2001-2010]. Salud Colectiva, 10(2), 171-184.
Uboldi MA.(2014). Enfermedades regionales: ¿Qué debemos hacer? Diapositiva presentada en el 7° Congreso Argentino de Infectología Pediátrica y 1° Jornadas de Enfermería en Infectología Pediátrica, 3-5 de abril de 2014, Sheraton
Córdoba Hotel, Córdoba, Argentina.
https://www.sap.org.ar/docs/congresos/2014/Infecto%20presentaciones/Uboldi_ fiebre_hemorrágica.pdf
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